There will be blood: hematopoiesis control by mediator subunit MED12

“There will be blood” from fibroblasts

The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. It is believed that HSCs emerge during embryogenesis from a population of hemogenic endothelial cells at sites like the aorta-gonad-mesonephros (AGM) region and placenta. Transplantation of HSCs is a widely utilized cell therapy for a range of gen...

There will be blood: targeting tumor vasculature.

Wherever there is cancer, there will be blood and blood vessels to support tumor growth. While the majority of anticancer drugs are designed to directly kill tumor cells, recent strategies are focusing on drugs that indirectly kill cancer cells by targeting the tumor microenvironment and tumor vasculature. This strategy gained a significant boost with the approval of the angiogenesis inhibitor ...

Will He Be There?

This paper focuses on an unsettling example of experimental labour - the Human Landing Catch (HLC). The HLC is a cheap and reliable technique to produce data on mosquito densities in a defined area. It requires only a human volunteer to sit over night with his legs exposed, a headlamp to spot mosquitoes, and a rubber tube and plastic cup to catch them as they come to feed on him. The HLC formed...

There Will Never Be Another You.

Yes, Virginia, there will be healthcare reform.

More than 100 years ago, a young girl named Virginia O'Hanlon wrote a letter to Santa Claus. 1 A newspaper reporter, impressed by the girl's innocence, edi-torialized this quest to believe in a fantasy representing good in the world by penning the famous line, " Yes, Virginia, there is a Santa Claus. " This story came to mind a few weeks ago, when I was having breakfast with my daughter-in-law ...